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Home > Columnists > Doug Strassler
May 31, 2017

"Derren Brown" Review

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OBAT PEMBENGKAKAN HATI Terobosan baru dalam biologi molekuler telah memungkinkan reklasifikasi obat enzim yang memetabolisme berdasarkan urutan asam amino mereka. Hal ini telah menyebabkan pemahaman yang lebih baik dari metabolisme obat dan interaksi obat. OBAT PEMBENGKAKAN HATI  Mayoritas enzim yang memetabolisme OBAT PEMBENGKAKAN HATI obat ini dapat baik diinduksi atau terhambat oleh obat-obatan atau bahan pengisi termasuk bahan makanan, polusi lingkungan dan asap rokok. OBAT PEMBENGKAKAN HATI Hampir OBAT PEMBENGKAKAN HATI  semua obat-obatan yang digunakan dalam anestesi dimetabolisme oleh hepatik tahap 1 atau tahap II enzim. Ulasan ini menganggap klasifikasi enzim yang memetabolisme obat, OBAT PEMBENGKAKAN HATI  menjelaskan mekanisme induksi enzim dan inhibisi, dan juga mempertimbangkan bagaimana tindakan obat sering digunakan oleh anaesthetists, termasuk opioid dan obat-obatan memblokir neuromuskular, dapat berubah oleh mekanisme ini. OBAT PEMBENGKAKAN HATI Faktor yang mempengaruhi metabolisme zat-zat asing (secara kolektif disebut xenobiotik) meliputi usia, seks, faktor keturunan dan genetik, penyakit, status OBAT PEMBENGKAKAN HATI Diet dan gizi, perubahan hormon dalam tubuh dan aktivitas enzim hati. Manusia yang terkena sejumlah zat lingkungan yang diketahui untuk mempengaruhi aktivitas enzim hati. OBAT PEMBENGKAKAN HATI  Zat ini termasuk bahan makanan, obat-obatan, rekreasi zat seperti alkohol dan tembakau, dan polutan yang ditemukan dalam rumah tangga dan di atmosfer. OBAT PEMBENGKAKAN HATI Baru-baru ini meningkatkan pemahaman kita tentang klasifikasi enzim hati sudah memampukan kita untuk memprediksi dengan cukup presisi bagaimana zat ini akan mempengaruhi fungsi enzim, dengan demikian mengubah metabolisme obat. OBAT PEMBENGKAKAN HATI

OBAT PEMBENGKAKAN HATI Xenobiotik dipecah oleh obat memetabolisme enzim (DMEs), yang ditemukan terutama dalam hati dan yang bertindak dengan membuat zat ini lebih larut dalam air. OBAT PEMBENGKAKAN HATI Secara tradisional, enzim-enzim ini ditetapkan sebagai tahap 1 atau tahap II enzim. Tahap I enzim terdiri dari enzim sitokrom P450, OBAT PEMBENGKAKAN HATI  sebelumnya dikenal sebagai campuran fungsi oksidase enzim dan bertanggung jawab untuk reaksi (terutama oksidasi dan hidroksilasi) yang mengubah grup fungsional untuk meningkatkan kelarutan airnya. OBAT PEMBENGKAKAN HATI Sitokrom P450 (CYP) isoenzim (nama berasal dari puncak penyerapan enzim 450 nm; OBAT PEMBENGKAKAN HATI  p menandakan pigmen) adalah keluarga haemoproteins yang oksidase terminal dari sistem oksidase campuran fungsi yang ditemukan di membran endoplasmic sarkoplasma [1]. OBAT PEMBENGKAKAN HATI Hadir sistem nomenklatur untuk isoenzim CYP berbagai mempekerjakan bertingkat tiga klasifikasi berdasarkan Konvensi biologi molekuler: angka dan huruf kapital menetapkan urutan asam amino, dengan sejumlah akhir menunjukkan individu enzim, misalnya menghambat CYP3A4 [2]. OBAT PEMBENGKAKAN HATI  Huruf perkataan menandakan gen yang mengkode enzim. Saat ini, lebih dari 270 keluarga CYP yang berbeda telah dijelaskan di kerajaan binatang, dengan 18 direkam di mamalia [3]. Dalam manusia ada 43 subfamili dan 57 enzim individu, masing-masing yang dikodekan oleh gen individu. OBAT PEMBENGKAKAN HATI

OBAT PEMBENGKAKAN HATI  Tahap II reaksi melibatkan konjugasi reaksi terjadi terutama di aktif denganrasio (bagian dari sitoplasma luar Sell) sebagian kecil dari sel-sel. OBAT PEMBENGKAKAN HATI Meskipun biasanya dianggap bahwa fase saya mendahului tahap II reaksi hal ini tidak selalu terjadi; Tahap II reaksi bisa mendahului fase saya jika ada kutub substrat. OBAT PEMBENGKAKAN HATI  Tujuan dari sistem multi enzim ini, yang telah berkembang selama Milenium dalam tumbuhan dan hewan, dapat dianggap OBAT PEMBENGKAKAN HATI sebagai bagian dari evolusi akibat perang tanaman-hewan. OBAT PEMBENGKAKAN HATI  Disintesis tanaman bahan kimia untuk perlindungan diri dan hewan harus mengembangkan OBAT PEMBENGKAKAN HATI  Gremlin pensil xenobiotic enzim seperti sitokrom P450 untuk detoxication bahan kimia ini [4]. OBAT PEMBENGKAKAN HATI Hal ini dapat sekarang dianggap respon adaptif untuk tantangan lingkungan di bahwa paparan zat beracun atau berbahaya atau apapun hasil kimia tantangan dalam ekspresi dari enzim bertanggung jawab untuk metabolisme dari racun tertentu. OBAT PEMBENGKAKAN HATI  Untuk sebagian besar ini adalah respon yang bermanfaat tetapi juga dapat mengakibatkan pembentukan suatu zat yang baik suatu obat aktif atau bahkan karsinogenik [5]. OBAT PEMBENGKAKAN HATI

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